Biostatistics and Computational Biology

PROJECT SUMMARY CORE 2 The Biostatistics and Computational Biology Core (Core 2) will be highly integrated with each individual P01 Project, the Administrative Core, and the Sample Processing Core (Core 1) by facilitating the management, analysis, and sharing of data derived from leukemia patient specimens, mouse models, and cell line models utilized in this proposal. Core 2 will support this P01 program using infrastructures and collaborative interactions that are largely pre-existing and will build additional infrastructure as needed to meet the Program Project goals. The overall goal of the Biostatistics and Computational Biology Core is to provide each Project with analytical, bioinformatical and statistical expertise for all data generated as part of this Program and to help discover and validate clinically meaningful biomarkers and novel therapies. Core 2 will assure that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science—use robust statistical techniques that are appropriately implemented. To achieve this goal Core 2 will implement state-of-the-art algorithms and analytical approaches to support discovery of biologically and clinically meaningful signals from transcriptomic and epigenetic data from cell and mouse models of leukemia. The Core will interface directly with the Core 1 to provide extensive statistical assessment of biospecimens, as well as with Core 3 for the integration and clinical translation of all findings. The Biostatistics and Computational Biology Core additionally provides mechanisms for effective data sharing to enable higher-level integration and synergy across Program Projects in collaboration with the Administrative Core and the Clinical Research Support Core (Core 3).