P30 - Core Grant for Vision Research

OVERALL COMPONENT Project Summary The main objectives of this NEI Core Grant for Vision Research is to support the study of the visual system's structure, development, and function in both healthy and diseased states. The ultimate goal is to prevent, alleviate, or cure vision-related diseases, as well as to restore lost vision, by utilizing advanced techniques. This will be achieved through three resource and service modules: I. Ocular Structure and Function (OSF) module: This module will provide NEI R01 investigators with the tools necessary for ocular phenotyping, including morphological analysis, light and electron microscopy, ocular imaging, and functional vision testing. Additionally, it will offer prototyping services. II. Advanced Imaging and Analysis (AIA) module: The goal is to visualize cellular dynamics of ocular tissues with high spatiotemporal resolution. This module will utilize state-of-the-art imaging modalities, such as spinning disk, multi-photon, and confocal microscopes, along with resources for quantitative image analysis and creation of visual content. III. Vision Bioinformatics & Computation (VBC) module: This module focuses on advancing vision research through bioinformatics and programming for customized research needs. VBC will support the analysis of functional genomics datasets, including Next-generation sequence (NGS) and "omics" data, and will establish custom-built software resources for advanced data processing. VBC will provide computational resources and user-friendly software packages for researchers of all levels of experience.