Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus

Project Summary/Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to long-term complications, including diabetes which is estimated to occur in >25% of patients. Research progress to date has been hindered by limitations due to study design and case ascertainment for diabetes. The DREAM study, an ongoing, prospective cohort study with serial assessments of glycemic status, undertaken by the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC), has been designed to directly investigate the incidence, etiology and pathophysiology of AP-related diabetes. The Ohio State University Clinical Center (OSU CC), one of the inaugural 10 clinical centers of the consortium, is a multi-disciplinary team (pancreatology, diabetology, radiology, and nutrition science) of nationally recognized experts that has worked collaboratively with the other T1DAPC CCs. Over the past four years, the OSU CC has been actively engaged to develop and contribute leadership to the T1DAPC organizational infrastructure and has been committed to enrolling and following up participants into the DREAM study. Overall goals of the current proposal are for OSU CC to continue its servant leadership to the T1DAPC over the next five years, foster research collaboration, and contribute to studies to understand the incidence and mechanisms of AP-related diabetes.