CAMPO consortium: HPV-related anogenital disease in people with HIV

The specific aims of the parent grant, the California-Mexico-Puerto Rico (CAMPO) consortium are: 1) To perform research focused on reducing the risk of cervical and anal cancer in men and women living with HIV and 2) To build local capacity for research focused on reducing the risk of cervical cancer and anal cancer in HIV-positive populations in Latin America. Two studies are currently proposed for the consortium. ULACNet- 101 is focused on defining optimal algorithms to diagnose anal and cervical high-grade squamous intraepithelial lesions (HSIL) in women living with HIV (WLWH) and anal HSIL in men, mostly men who have sex with men (MSMLWH). The results of various tests (cytology, HPV genotyping and methylation) will be analyzed alone and in combination to determine the optimal diagnostic testing regimen to detect HSIL. ULACNet-104 is designed to study the relationship between anal high-risk HPV (hr-HPV) infection and the anal microbiome among three distinct populations of Hispanic people living with HIV (PLWH) in California, Mexico and Puerto Rico (PR). This study is designed to take advantage of the extensive infrastructure and data generated by CAMPO to determine how differences in the anal microbiota between Hispanic PLWH in PR, Mexico and California may inform the role of the anal microbiome in potentiating anal HPV-related anal disease in these high-risk populations. The specific aims of this supplement are: Aim 1: To identify optimal screening strategies among HIV-positive women in Mexico and Puerto Rico for anal and cervical high-grade squamous intraepithelial lesion (HSIL) detection, including cytology, HPV extended-typing and methylation markers (ULACNet-101); Aim 2. Study the relationship between anal high-risk HPV (hr-HPV) infection and the anal microbiome among three distinct populations of Hispanic people living with HIV (PLWH) in California, Mexico and Puerto Rico (PR) (ULACNet-104); Aim 3. Study the relationship between anal high-grade squamous intraepithelial lesions (HSIL) and the anal microbiome among three distinct populations of Hispanic PLWH with anal hr-HPV infection in California, Mexico and PR (ULACNet-104). The purpose of this supplement is to allow us to continue enrollment in ULACNet-101 and ULACNet-104 to reach our target accrual, to clean and lock ULACNet-101 and ULACNet-104 databases, complete laboratory testing for ULACNet-101, analyze the ULACNet-101 and ULACNet-104 data, and prepare them for publication.