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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Identification of Novel Syk/Raf-1 Mediated CLR Ligands as Vaccine Adjuvants
- Institution
- University of Montana, MT
- Principal investigator
- Jay Evans
- Funding
- $1.6M
- Duration
- 2025–2026
48/100
Abstract
The contractor proposes to screen libraries of synthetic putative CLR agonists that induce Th17 or Th17/Th1 immunity as adjuvants for bacterial and fungal pathogens. Age-specific immune phenotyping will be conducted in mice and with human cells and optimized, formulated lead candidates will be tested in models of Mtb and coccidioidomycosis.
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